ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells

ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells

Abstract Background Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to the complexity of heterogeneity, culminating in preferential resistance t...

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Bibliographic Details
Main Authors: Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo, Gang Li
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioblastoma
Glioma stem cells
ARPC1B
Radiotherapy resistance
AZD6738
Online Access:https://doi.org/10.1186/s13046-022-02526-8

Internet

https://doi.org/10.1186/s13046-022-02526-8

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