Case Report: Progressive central conducting lymphatic abnormalities in the RASopathies. Two case reports, including successful treatment by MEK inhibition

Case Report: Progressive central conducting lymphatic abnormalities in the RASopathies. Two case reports, including successful treatment by MEK inhibition

The RASopathies are a group of genetic conditions resulting from mutations within the RAS/mitogen-activated protein kinase (RAS-MAPK) pathway. Lymphatic abnormalities are commonly associated with these conditions, however central conducting lymphatic abnormalities (CCLA) have only recently been desc...

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Bibliographic Details
Main Authors: Kristiana Gordon, Matthew Moore, Malou Van Zanten, Julian Pearce, Maxim Itkin, Brendan Madden, Lakshmi Ratnam, Peter S. Mortimer, Rani Nagaraja, Sahar Mansour
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
chylous
lymphoedema
chylothorax
chylopericardium
noonan syndrome
lymphedema
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1001105/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.1001105/full

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