Bruceine a exerts antitumor effect against colon cancer by accumulating ROS and suppressing PI3K/Akt pathway

Bruceine a exerts antitumor effect against colon cancer by accumulating ROS and suppressing PI3K/Akt pathway

Bruceine A (BA), a quassic ester from bruceine javanica, regulates diverse intracellular signal transduction pathways and manifests a variety of biological activities, however, its pharmacological mechanism in treating colon cancer (CC) is unclear. In this study, we investigated the anticancer effec...

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Bibliographic Details
Main Authors: Chaozheng Zhang, Yuening Cao, Yi Zuo, Hongbin Cheng, Changqun Liu, Xila Xia, Bo Ren, Yun Deng, Maolin Wang, Jun Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
Bruceine A (BA)
colon cancer
network pharmacology
PI3K/AKT
molecular dock
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1149478/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1149478/full

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