Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

We analyzed the spike protein S1/S2 cleavage of selected strains of a prototype coronavirus, mouse hepatitis virus (MHV) by the cellular protease furin, in order to understand the structural requirements underlying the sequence selectivity of the scissile segment. The probability of cleavage of sele...

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Bibliographic Details
Main Authors: Annette Choi, Ekaterina D. Kots, Deanndria T. Singleton, Harel Weinstein, Gary R. Whittaker
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Virus Research
Subjects:
furin
mouse hepatitis virus
coronavirus
spike protein
structural criteria for spike cleavage by furin
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170223002459

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http://www.sciencedirect.com/science/article/pii/S0168170223002459

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