Downstream Effects of Mutations in <i>SOD1</i> and <i>TARDBP</i> Converge on Gene Expression Impairment in Patient-Derived Motor Neurons

Downstream Effects of Mutations in <i>SOD1</i> and <i>TARDBP</i> Converge on Gene Expression Impairment in Patient-Derived Motor Neurons

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is still not understood. To generate novel hypotheses...

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Bibliographic Details
Main Authors: Banaja P. Dash, Axel Freischmidt, Jochen H. Weishaupt, Andreas Hermann
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis (ALS)
human induced pluripotent stem cells (iPSC)
motor neurons (MN)
RNA sequencing (RNA-Seq)
differentially expressed genes (DEG)
protein-protein interaction (PPI)
Online Access:https://www.mdpi.com/1422-0067/23/17/9652

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https://www.mdpi.com/1422-0067/23/17/9652

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