Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3–SOCS3 Pathway

Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3–SOCS3 Pathway

BackgroundVentilator-induced lung injury (VILI) is characterized by vascular barrier dysfunction and suppression of alveolar fluid clearance (AFC). Obesity itself leads to chronic inflammation, which may initiate an injurious cascade to the lungs and simultaneously induce a protective feedback. In t...

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Bibliographic Details
Main Authors: Shih-Wei Wu, Chung-Kan Peng, Shu-Yu Wu, Yu Wang, Sung-Sen Yang, Shih-En Tang, Kun-Lun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
obesity
ventilator-induced lung injury (VILI)
suppressor of cytokine signaling 3 (SOCS3)
hesperetin
WNK lysine deficient protein kinase 4 (WNK4)
alveolar fluid clearance (AFC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.720844/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.720844/full

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