Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity

Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity

Summary: Thymocyte development requires precise control of PI3K-Akt signaling to promote proliferation and prevent leukemia and autoimmune disorders. Here, we show that ablating individual clusters of the miR-17∼92 family has a negligible effect on thymocyte development, while deleting the entire fa...

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Bibliographic Details
Main Authors: Kunyu Liao, Pengda Chen, Mengdi Zhang, Jiazhen Wang, Teri Hatzihristidis, Xiaoxi Lin, Liang Yang, Nan Yao, Chenfeng Liu, Yazhen Hong, Xia Li, Hong Liu, Juan Carlos Zúñiga-Pflücker, Paul E. Love, Xiang Chen, Wen-Hsien Liu, Bin Zhao, Changchun Xiao
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724005898

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http://www.sciencedirect.com/science/article/pii/S2211124724005898

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