Comparative functional genomic analysis of Alzheimer’s affected and naturally aging brains

Comparative functional genomic analysis of Alzheimer’s affected and naturally aging brains

Background Alzheimer’s disease (AD) is a prevalent progressive neurodegenerative human disease whose cause remains unclear. Numerous initially highly hopeful anti-AD drugs based on the amyloid-β (Aβ) hypothesis of AD have failed recent late-phase tests. Natural aging (AG) is a high-risk factor for A...

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Bibliographic Details
Main Authors: Yi-Shian Peng, Chia-Wei Tang, Yi-Yun Peng, Hung Chang, Chien-Lung Chen, Shu-Lin Guo, Li-Ching Wu, Min-Chang Huang, Hoong-Chien Lee
Format: Article
Language:English
Published: PeerJ Inc. 2020-03-01
Series:PeerJ
Subjects:
Alzheimer’s disease
Aging
Proteasome
Oxidative phosphorylation
Novel AD target genes
Tau and Aβ pathologies
Online Access:https://peerj.com/articles/8682.pdf

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https://peerj.com/articles/8682.pdf

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