Epigenetic MMR defect identifies a risk group not accounted for through traditional risk stratification algorithms in endometrial cancer

Epigenetic MMR defect identifies a risk group not accounted for through traditional risk stratification algorithms in endometrial cancer

PurposeWe sought to evaluate the contribution of mismatch repair (MMR) status to traditional risk stratification algorithms used to predict nodal involvement and recurrence in a large single-institution cohort.MethodsEndometrioid endometrial cancer (EC) cases from 2014-2020 were evaluated. MMR immun...

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Bibliographic Details
Main Authors: Courtney J. Riedinger, Morgan Brown, Paulina J. Haight, Floor J. Backes, David E. Cohn, Paul J. Goodfellow, Casey M. Cosgrove
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
mismatch repair deficiency (MMR)
epigenetic loss
Lynch syndrome
biomarker
risk stratification
endometrial cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1147657/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1147657/full

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