Ouabain promotes claudin-1, -2, and -4 autophagic degradation through oxidative stress and AMPK activation in MDCK cells

Ouabain promotes claudin-1, -2, and -4 autophagic degradation through oxidative stress and AMPK activation in MDCK cells

Epithelial cells transport substances through the cellular and paracellular pathways. The last one depends on tight junctions, particularly on claudins, the family of integral membrane proteins responsible for the permeability and selectivity of these junctions. 300 nM ouabain (OUA) induces endocyto...

Full description

Bibliographic Details
Main Authors: Jessica P. Campos-Blázquez, Catalina Flores-Maldonado, Juan M. Gallardo, José Bonilla-Delgado, Alan A. Pedraza-Ramírez, Octavio López-Méndez, Enoc M. Cortés-Malagón, Rubén G. Contreras
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autophagy Reports
Subjects:
epithelia
lc3
p62
reactive oxygen species
tight junctions
rapamycin
ter
ulk1
Online Access:http://dx.doi.org/10.1080/27694127.2023.2256146

Internet

http://dx.doi.org/10.1080/27694127.2023.2256146

Similar Items