T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

Leukemia stem cells (LSCs) are regarded as the origins and key therapeutic targets of leukemia, but limited knowledge is available on the key determinants of LSC ‘stemness’. Using single-cell RNA-seq analysis, we identify a master regulator, SPI1, the LSC-specific expression of which determines the...

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Bibliographic Details
Main Authors: Haichuan Zhu, Liuzhen Zhang, Yilin Wu, Bingjie Dong, Weilong Guo, Mei Wang, Lu Yang, Xiaoying Fan, Yuliang Tang, Ningshu Liu, Xiaoguang Lei, Hong Wu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
bone marrow
thymus
human T-ALL cell line
Online Access:https://elifesciences.org/articles/38314

Internet

https://elifesciences.org/articles/38314

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