A Novel Drug Modulator Diarylheptanoid (<i>t</i><i>rans</i>-1,7-Diphenyl-5-hydroxy-1-heptene) from <i>Curcuma comosa</i> Rhizomes for P-glycoprotein Function and Apoptosis Induction in K652/ADR Leukemic Cells

A Novel Drug Modulator Diarylheptanoid (<i>t</i><i>rans</i>-1,7-Diphenyl-5-hydroxy-1-heptene) from <i>Curcuma comosa</i> Rhizomes for P-glycoprotein Function and Apoptosis Induction in K652/ADR Leukemic Cells

<i>Curcuma comosa</i> has been used in traditional Thai medicine to treat menstrual cycle-related symptoms in women. This study aims to evaluate the diarylheptanoid drug modulator, <i>t</i><i>rans</i>-1,7-diphenyl-5-hydroxy-1-heptene (DHH), in drug-resistant K562/...

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Bibliographic Details
Main Authors: Natsima Viriyaadhammaa, Suwit Duangmano, Aroonchai Saiai, Montree Tungjai, Pornngarm Dejkriengkraikul, Singkome Tima, Sawitree Chiampanichayakul, Jeffrey Krise, Songyot Anuchapreeda
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Curcuma comosa</i>
diarylheptanoid
<i>trans</i>-1,7-diphenyl-5-hydroxy-1-heptene
multidrug resistance
MDR modulator
antileukemia
Online Access:https://www.mdpi.com/1422-0067/23/16/8989

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https://www.mdpi.com/1422-0067/23/16/8989

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