Stability of blood‐based biomarkers of Alzheimer's disease over multiple freeze‐thaw cycles

Abstract Introduction Freeze‐thaw instability may contribute to preanalytical variation in blood‐based biomarker studies. We investigated the effects of up to four freeze‐thaw cycles on single molecule array immunoassays of serum neurofilament light chain and plasma total tau, amyloid β 1–40 (Aß40),...

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Bibliographic Details
Main Authors: Ashvini Keshavan, Amanda Heslegrave, Henrik Zetterberg, Jonathan M. Schott
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Online Access:https://doi.org/10.1016/j.dadm.2018.06.001