Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression

Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression

Mechanisms of action of squalamine in human vascular endothelial cells indicate that this compound attaches to cell membranes, potentially interacting with calmodulin, Na<sup>+</sup>/H<sup>+</sup> exchanger isoform NHE3 and other signaling pathways involved in the angiogenic...

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Bibliographic Details
Main Authors: Colin Sterling, Diana Márquez-Garbán, Jaydutt V. Vadgama, Richard J. Pietras
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
malignancy
squalamine
tumor-associated angiogenesis
vascular endothelial growth factor (VEGF)
aminosterol
MAPK
Online Access:https://www.mdpi.com/2072-6694/14/20/5154

Internet

https://www.mdpi.com/2072-6694/14/20/5154

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