Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression
Mechanisms of action of squalamine in human vascular endothelial cells indicate that this compound attaches to cell membranes, potentially interacting with calmodulin, Na<sup>+</sup>/H<sup>+</sup> exchanger isoform NHE3 and other signaling pathways involved in the angiogenic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/5154 |
| _version_ | 1797474501852659712 |
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| author | Colin Sterling Diana Márquez-Garbán Jaydutt V. Vadgama Richard J. Pietras |
| author_facet | Colin Sterling Diana Márquez-Garbán Jaydutt V. Vadgama Richard J. Pietras |
| author_sort | Colin Sterling |
| collection | DOAJ |
| description | Mechanisms of action of squalamine in human vascular endothelial cells indicate that this compound attaches to cell membranes, potentially interacting with calmodulin, Na<sup>+</sup>/H<sup>+</sup> exchanger isoform NHE3 and other signaling pathways involved in the angiogenic process. Thus, squalamine elicits blockade of VEGF-induced endothelial tube-like formation in vitro. Further, squalamine reduces growth of several preclinical models of human cancers in vivo and acts to stop metastatic tumor spread, actions due largely to blockade of angiogenesis induced by the tumor and tumor microenvironment. Squalamine in Phase I/II trials, alone or combined with standard care, shows promising antitumor activity with limited side-effects in patients with advanced solid cancers. Increased attention on squalamine regulation of signaling pathways with or without combination treatments in solid malignancies deserves further study. |
| first_indexed | 2024-03-09T20:31:01Z |
| format | Article |
| id | doaj.art-53cad8497f994c49a015085157f0faf8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:31:01Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-53cad8497f994c49a015085157f0faf82023-11-23T23:22:51ZengMDPI AGCancers2072-66942022-10-011420515410.3390/cancers14205154Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer ProgressionColin Sterling0Diana Márquez-Garbán1Jaydutt V. Vadgama2Richard J. Pietras3Division of Cancer Research and Training, Charles Drew University School of Medicine and Science, Los Angeles, CA 90059, USADivision of Hematology-Oncology, Department of Medicine, UCLA David Geffen School of Medicine and UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USADivision of Cancer Research and Training, Charles Drew University School of Medicine and Science, Los Angeles, CA 90059, USADivision of Cancer Research and Training, Charles Drew University School of Medicine and Science, Los Angeles, CA 90059, USAMechanisms of action of squalamine in human vascular endothelial cells indicate that this compound attaches to cell membranes, potentially interacting with calmodulin, Na<sup>+</sup>/H<sup>+</sup> exchanger isoform NHE3 and other signaling pathways involved in the angiogenic process. Thus, squalamine elicits blockade of VEGF-induced endothelial tube-like formation in vitro. Further, squalamine reduces growth of several preclinical models of human cancers in vivo and acts to stop metastatic tumor spread, actions due largely to blockade of angiogenesis induced by the tumor and tumor microenvironment. Squalamine in Phase I/II trials, alone or combined with standard care, shows promising antitumor activity with limited side-effects in patients with advanced solid cancers. Increased attention on squalamine regulation of signaling pathways with or without combination treatments in solid malignancies deserves further study.https://www.mdpi.com/2072-6694/14/20/5154malignancysqualaminetumor-associated angiogenesisvascular endothelial growth factor (VEGF)aminosterolMAPK |
| spellingShingle | Colin Sterling Diana Márquez-Garbán Jaydutt V. Vadgama Richard J. Pietras Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression Cancers malignancy squalamine tumor-associated angiogenesis vascular endothelial growth factor (VEGF) aminosterol MAPK |
| title | Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression |
| title_full | Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression |
| title_fullStr | Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression |
| title_full_unstemmed | Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression |
| title_short | Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression |
| title_sort | squalamines in blockade of tumor associated angiogenesis and cancer progression |
| topic | malignancy squalamine tumor-associated angiogenesis vascular endothelial growth factor (VEGF) aminosterol MAPK |
| url | https://www.mdpi.com/2072-6694/14/20/5154 |
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