Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination

Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination

Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccina...

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Bibliographic Details
Main Authors: David Repáraz, Marta Ruiz, Leyre Silva, Belén Aparicio, Josune Egea, Elizabeth Guruceaga, Daniel Ajona, Yaiza Senent, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Sandra Hervás-Stubbs, Juan José Lasarte, Diana Llopiz, Pablo Sarobe
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
immunosuppressive DC
antitumor therapeutic vaccination
monocyte depletion
anti-PD-1
gemcitabine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.991311/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.991311/full

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