Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigated the mechanisms driving human CD4+ T cell-mediate...

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Bibliographic Details
Main Authors: Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Negar Farzam-kia, Victoria Hannah Mamane, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Wendy Klement, Florent Lemaître, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
human oligodendrocytes
neuroinflammation
multiple sclerosis
Th17 cells
granzyme B
CD4 T lymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.850616/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.850616/full

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