Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease

ABSTRACTAlthough smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Food and Drug Administration for the treatment of small...

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Main Authors: Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
orthopoxvirus
nucleoside
vaccinia
monkeypox
Mpox
murine
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03586-23

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https://journals.asm.org/doi/10.1128/spectrum.03586-23

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