The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

Many enzymes make “mistakes”. Consequently, repair enzymes have evolved to correct these mistakes. For example, lactate dehydrogenase (LDH) and mitochondrial malate dehydrogenase (mMDH) slowly catalyze the reduction of 2-oxoglutarate (2-OG) to the oncometabolite l-2-hydroxyglutarate (l-2-HG). l-2-HG...

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Bibliographic Details
Main Authors: Vivek A. Hariharan, Travis T. Denton, Sarah Paraszcszak, Kyle McEvoy, Thomas M. Jeitner, Boris F. Krasnikov, Arthur J. L. Cooper
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Biology
Subjects:
ω-Amidase
asparagine transaminase
2-hydroxyglutarate
2-hydroxyglutaramate
2-hydroxysuccinamate
glutamine synthetase
glutamine transaminases
2-oxoglutaramate
2-oxoglutarate
Online Access:http://www.mdpi.com/2079-7737/6/2/24

Internet

http://www.mdpi.com/2079-7737/6/2/24

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