A cell-permeable peptide inhibitor of p55PIK signaling alleviates suture-induced corneal neovascularization and inflammation

A cell-permeable peptide inhibitor of p55PIK signaling alleviates suture-induced corneal neovascularization and inflammation

To prepare an ophthalmic solution with a cell-permeable TAT peptide (TAT-N24) as the main cell-permeable peptide inhibitor of p55PIK signaling and observe its therapeutic effect on suture-induced corneal neovascularization (CNV) in rats. Sprague-Dawley rats were used to establish a corneal suture (C...

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Bibliographic Details
Main Authors: Jingyi Huang, Yiran Zhang, Tao Lin, Hui Yin, Yingzhe Pan, Meijuan Zhu, Min Zhang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Corneal suture
Corneal neovascularization
Inflammation
TAT-N24
P55PIK
HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023020765

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http://www.sciencedirect.com/science/article/pii/S2405844023020765

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