Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in patients with type 1 diabetes, results in recruitme...

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Bibliographic Details
Main Authors: Stephanie J. Hanna, Terri C. Thayer, Emma J. S. Robinson, Ngoc-Nga Vinh, Nigel Williams, Laurie G. Landry, Robert Andrews, Qi Zhuang Siah, Pia Leete, Rebecca Wyatt, Martina A. McAteer, Maki Nakayama, F. Susan Wong, Jennie H. M. Yang, Timothy I. M. Tree, Johnny Ludvigsson, Colin M. Dayan, Danijela Tatovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
nanoparticles
proinsulin peptide
type 1 diabetes
immunomodulation
scRNAseq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276255/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276255/full

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