Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in patients with type 1 diabetes, results in recruitme...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Stephanie J. Hanna, Terri C. Thayer, Emma J. S. Robinson, Ngoc-Nga Vinh, Nigel Williams, Laurie G. Landry, Robert Andrews, Qi Zhuang Siah, Pia Leete, Rebecca Wyatt, Martina A. McAteer, Maki Nakayama, F. Susan Wong, Jennie H. M. Yang, Timothy I. M. Tree, Johnny Ludvigsson, Colin M. Dayan, Danijela Tatovic
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Frontiers Media S.A. 2023-10-01
Ráidu:Frontiers in Immunology
Fáttát:
nanoparticles
proinsulin peptide
type 1 diabetes
immunomodulation
scRNAseq
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276255/full

Interneahtta

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276255/full

Geahča maid