Monitoring the Intracellular pH and Metabolic State of Cancer Cells in Response to Chemotherapy Using a Combination of Phosphorescence Lifetime Imaging Microscopy and Fluorescence Lifetime Imaging Microscopy

Monitoring the Intracellular pH and Metabolic State of Cancer Cells in Response to Chemotherapy Using a Combination of Phosphorescence Lifetime Imaging Microscopy and Fluorescence Lifetime Imaging Microscopy

The extracellular matrix (ECM), in which collagen is the most abundant protein, impacts many aspects of tumor physiology, including cellular metabolism and intracellular pH (pHi), as well as the efficacy of chemotherapy. Meanwhile, the role of collagen in differential cell responses to treatment wit...

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Bibliographic Details
Main Authors: Irina Druzhkova, Anastasiya Komarova, Elena Nikonova, Vadim Baigildin, Artem Mozherov, Yuliya Shakirova, Uliana Lisitsa, Vladislav Shcheslavskiy, Nadezhda Ignatova, Evgeny Shirshin, Marina Shirmanova, Sergey Tunik
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
intracellular pH
metabolism
HCT116 cell line
collagen
FOLFOX
PLIM
Online Access:https://www.mdpi.com/1422-0067/25/1/49

Internet

https://www.mdpi.com/1422-0067/25/1/49

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