Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as start...

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Bibliographic Details
Main Authors: Karène Urgin, Mouhamad Jida, Katharina Ehrhardt, Tobias Müller, Michael Lanzer, Louis Maes, Mourad Elhabiri, Elisabeth Davioud-Charvet
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/22/1/161