Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Abstract The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6 mice, and caused severe neuro damage including neu...

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Bibliographic Details
Main Authors: Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv, Fang Han
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Molecular Medicine
Subjects:
Chronic intermittent hypoxia
Cognitive deficits
ROS
Lipid droplets
JNK/SREBP/ACC pathway
Online Access:https://doi.org/10.1186/s10020-021-00427-8

Internet

https://doi.org/10.1186/s10020-021-00427-8

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