Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice

Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice

Plasma concentration of Cystatin C (CysC) level is a biomarker of glomerular filtration rate in the kidney. We use a Systems Genetics approach to investigate the genetic determinants of plasma CysC concentration. To do so we perform Quantitative Trait Loci (QTL) and expression QTL (eQTL) analysis of...

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Bibliographic Details
Main Authors: M. Nazmul Huda, Melissa VerHague, Jody Albright, Tangi Smallwood, Timothy A. Bell, Excel Que, Darla R. Miller, Baback Roshanravan, Hooman Allayee, Fernando Pardo Manuel de Villena, Brian J. Bennett
Format: Article
Language:English
Published: Oxford University Press 2020-07-01
Series:G3: Genes, Genomes, Genetics
Subjects:
quantitative trait loci
multi parental models
cystatin c
kidney biomarkers
type-i interferon signalling pathway
multiparent advanced generation inter-cross (magic)
multiparental populations
mpp
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.120.401275

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http://g3journal.org/lookup/doi/10.1534/g3.120.401275

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