Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

<p>Abstract</p> <p>Background</p> <p>High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical questions. Statistical and computational methods are key for drawing meani...

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Bibliographic Details
Main Authors: Hansen Kasper D, Purdom Elizabeth, Bullard James H, Dudoit Sandrine
Format: Article
Language:English
Published: BMC 2010-02-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/11/94