AA147 ameliorates post-cardiac arrest cerebral ischemia/reperfusion injury through the co-regulation of the ATF6 and Nrf2 signaling pathways

AA147 ameliorates post-cardiac arrest cerebral ischemia/reperfusion injury through the co-regulation of the ATF6 and Nrf2 signaling pathways

Ischemia/reperfusion caused by cardiac arrest (CA) disturbs endoplasmic reticulum (ER) homeostasis and redox balance in neurons. AA147, originally developed as a pharmacologic activator of the activating transcription factor 6 (ATF6), can protect multiple tissues from ischemia/reperfusion injury (IR...

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Bibliographic Details
Main Authors: Zhu Yuan, Liping Lu, Yingtao Lian, Yuanrui Zhao, Tingting Tang, Song Xu, Zhun Yao, Zhui Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
cardiac arrest
AA147
neuroprotection
ischemia/reperfusion injury
endoplasmic reticulum stress
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1028002/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1028002/full

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