R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase <i>cis</i>-P3H-Mediated Selective Synthesis of (2S,3R)-3-Hydroxypipecolic Acid

R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase <i>cis</i>-P3H-Mediated Selective Synthesis of (2S,3R)-3-Hydroxypipecolic Acid

Pipecolic acid (Pip) and its derivative hydroxypipecolic acids, such as (2S,3R)-3-hydroxypipecolic acid (<i>cis</i>-3-L-HyPip), are components of many natural and synthetic bioactive molecules. Fe(II)/α-ketoglutaric acid (Fe(II)/2-OG)-dependent dioxygenases can catalyze the hydroxylation...

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Bibliographic Details
Main Authors: Jiaojiao Guan, Yilei Lu, Zixuan Dai, Songyin Zhao, Yan Xu, Yao Nie
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
L-pipecolic acid
dioxygenase
hydroxypipecolic acid
“handlebar” mode
site-directed saturation mutagenesis
Online Access:https://www.mdpi.com/1420-3049/28/4/1854

Internet

https://www.mdpi.com/1420-3049/28/4/1854

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