A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen <named-content content-type="genus-species">Rickettsia parkeri</named-content> Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics
ABSTRACT Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2019-12-01
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| Series: | mSphere |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00536-19 |