A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen <named-content content-type="genus-species">Rickettsia parkeri</named-content> Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen <named-content content-type="genus-species">Rickettsia parkeri</named-content> Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

ABSTRACT Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of e...

Full description

Bibliographic Details
Main Authors: Vida Ahyong, Charles A. Berdan, Thomas P. Burke, Daniel K. Nomura, Matthew D. Welch
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
Rickettsia
isoprenoids
metabolic parasitism
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00536-19

Similar Items

Similar Items