BCR-ABL Independent Mechanisms of Resistance in Chronic Myeloid Leukemia

Not all chronic myeloid leukemia (CML) patients are cured with tyrosine kinase inhibitors (TKIs), and a proportion of them develop resistance. Recently, continuous BCR-ABL gene expression has been found in resistant cells with undetectable BCR-ABL protein expression, indicating that resistance may o...

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Bibliographic Details
Main Authors: Federica Loscocco, Giuseppe Visani, Sara Galimberti, Antonio Curti, Alessandro Isidori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00939/full