Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors

Hyperactive Akt1 Signaling Increases Tumor Progression and DNA Repair in Embryonal Rhabdomyosarcoma RD Line and Confers Susceptibility to Glycolysis and Mevalonate Pathway Inhibitors

In pediatric rhabdomyosarcoma (RMS), elevated Akt signaling is associated with increased malignancy. Here, we report that expression of a constitutively active, myristoylated form of Akt1 (myrAkt1) in human RMS RD cells led to hyperactivation of the mammalian target of rapamycin (mTOR)/70-kDa riboso...

Full description

Bibliographic Details
Main Authors: Silvia Codenotti, Daniela Zizioli, Luca Mignani, Sara Rezzola, Giovanna Tabellini, Silvia Parolini, Arianna Giacomini, Michela Asperti, Maura Poli, Delia Mandracchia, Marika Vezzoli, Simona Bernardi, Domenico Russo, Stefania Mitola, Eugenio Monti, Luca Triggiani, Davide Tomasini, Stefano Gastaldello, Matteo Cassandri, Rossella Rota, Francesco Marampon, Alessandro Fanzani
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Akt
DNA repair
2-deoxy-D-glucose
lovastatin
rhabdomyosarcoma
Online Access:https://www.mdpi.com/2073-4409/11/18/2859

Internet

https://www.mdpi.com/2073-4409/11/18/2859

Similar Items