Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model

Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model

ObjectiveDisruption of the blood-spinal cord barrier (BSCB) with subsequent edema formation and further neuroinflammation contributes to aggravation of spinal cord injury (SCI). We aimed to observe the effect of antagonizing the binding of the neuropeptide Substance-P (SP) to its neurokinin-1 (NK1)...

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Bibliographic Details
Main Authors: Guoli Zheng, Anna-Kathrin Harms, Mohamed Tail, Hao Zhang, Alan Nimmo, Thomas Skutella, Karl Kiening, Andreas Unterberg, Klaus Zweckberger, Alexander Younsi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal cord injury
animal model
neurokinin-1 (NK1) antagonist
blood spinal cord barrier
inflammation
behavioral assessment
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1128545/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1128545/full

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