Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.

Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.

BACKGROUND: Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available. PRINCIPAL FINDINGS: In wound edge biopsies from human venous leg ulcers we found a striking upregulation of dermal N-cadherin, Zonula Occludens...

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Bibliographic Details
Main Authors: Ariadna Mendoza-Naranjo, Peter Cormie, Antonio E Serrano, Rebecca Hu, Shay O'Neill, Chiuhui Mary Wang, Christopher Thrasivoulou, Kieran T Power, Alexis White, Thomas Serena, Anthony R J Phillips, David L Becker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3352877?pdf=render

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http://europepmc.org/articles/PMC3352877?pdf=render

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