Smad7 Antisense Oligonucleotide in Crohn’s Disease: A Re-Evaluation and Explanation for the Discordant Results of Clinical Trials

Smad7 Antisense Oligonucleotide in Crohn’s Disease: A Re-Evaluation and Explanation for the Discordant Results of Clinical Trials

In Crohn’s disease (CD) and ulcerative colitis (UC), the major inflammatory bowel diseases (IBD) in human beings, the tissue-damaging inflammatory response is characterized by elevated levels of Suppressor of Mothers Against Decapentaplegic (Smad)7, an inhibitor of the immunosuppressive cytokine Tra...

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Bibliographic Details
Main Authors: Giovanni Monteleone, Carmine Stolfi
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
inflammatory bowel disease
TGF-beta
cytokines
mucosal inflammation
Online Access:https://www.mdpi.com/1999-4923/15/1/95

Internet

https://www.mdpi.com/1999-4923/15/1/95

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