Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion

Bacterial Lipoproteins Shift Cellular Metabolism to Glycolysis in Macrophages Causing Bone Erosion

ABSTRACT Belonging to a group of membrane proteins, bacterial lipoproteins (LPPs) are defined by a unique lipid structure at their N-terminus providing the anchor in the bacterial cell membrane. In Gram-positive bacteria, LPPs play a key role in host immune activation triggered through a Toll-like r...

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Bibliographic Details
Main Authors: Minh-Thu Nguyen, Zhicheng Hu, Majd Mohammad, Hannah Schöttler, Silke Niemann, Michelle Schultz, Katarzyna Barczyk-Kahlert, Tao Jin, Heiko Hayen, Mathias Herrmann
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
bone marrow-derived macrophages
Pam2Cys
Pam3Cys
bacterial lipoprotein
bone erosion
cellular metabolism
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04293-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04293-22

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