Isoniazid improves cognitive performance, clears Aβ plaques, and protects dendritic synapses in APP/PS1 transgenic mice

Isoniazid improves cognitive performance, clears Aβ plaques, and protects dendritic synapses in APP/PS1 transgenic mice

Background and objectiveAlzheimer’s disease (AD) is characterized by amyloid β (Aβ) aggregation and neuroinflammation. This study aimed to investigate the therapeutic effect of isoniazid (INH) against AD.MethodsThe APP/PS1 transgenic mouse model of AD was adopted. The APP/PS1 mice received oral INH...

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Bibliographic Details
Main Authors: Jiacheng Chen, Ning Guo, Yuting Ruan, Yingren Mai, Wang Liao, Yanqing Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
amyloid β
isoniazid
neuroinflammation
dendritic synapse
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1105095/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1105095/full

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