Altered retinoic acid metabolism in diabetic mouse kidney identified by O isotopic labeling and 2D mass spectrometry.

Numerous metabolic pathways have been implicated in diabetes-induced renal injury, yet few studies have utilized unbiased systems biology approaches for mapping the interconnectivity of diabetes-dysregulated proteins that are involved. We utilized a global, quantitative, differential proteomic appro...

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Main Authors: Jonathan M Starkey, Yingxin Zhao, Rovshan G Sadygov, Sigmund J Haidacher, Wanda S Lejeune, Nilay Dey, Bruce A Luxon, Maureen A Kane, Joseph L Napoli, Larry Denner, Ronald G Tilton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2885420?pdf=render