Physiological and pathological roles of PGAM5: An update and future trend

Summary: PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis,...

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Bibliographic Details
Main Authors: Weibin He, Wenlong He, Zhongchan Sun, Pengcheng He
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027664