Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia
We established the COVID Human Genetic Effort (www.covidhge.com) to discover the human genetic and immunological bases of the vast interindividual clinical variability between humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that about 3% of patients with l...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2021-02-01
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| Series: | Comptes Rendus Biologies |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.36/ |
| _version_ | 1797651243320999936 |
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| author | Bastard, Paul Zhang, Qian Cobat, Aurélie Jouanguy, Emmanuelle Zhang, Shen-Ying Abel, Laurent Casanova, Jean-Laurent |
| author_facet | Bastard, Paul Zhang, Qian Cobat, Aurélie Jouanguy, Emmanuelle Zhang, Shen-Ying Abel, Laurent Casanova, Jean-Laurent |
| author_sort | Bastard, Paul |
| collection | DOAJ |
| description | We established the COVID Human Genetic Effort (www.covidhge.com) to discover the human genetic and immunological bases of the vast interindividual clinical variability between humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that about 3% of patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia were ill because of inborn errors of genes controlling type I interferon (IFN)-dependent immunity (which controls influenza virus), and at least 10% of patients with life-threatening COVID-19 pneumonia had neutralizing auto-Abs against some of the 17 individual type I IFNs. These findings indicate that impaired type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 13% of patients. These discoveries pave the way for further research into unexplained severe cases, and provide a rationale for preventing and treating the disease in individuals at risk, with recombinant type I IFNs. |
| first_indexed | 2024-03-11T16:13:07Z |
| format | Article |
| id | doaj.art-54139b44ecd4477da8f5660c9a09e8f0 |
| institution | Directory Open Access Journal |
| issn | 1768-3238 |
| language | English |
| last_indexed | 2024-03-11T16:13:07Z |
| publishDate | 2021-02-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj.art-54139b44ecd4477da8f5660c9a09e8f02023-10-24T14:25:18ZengAcadémie des sciencesComptes Rendus Biologies1768-32382021-02-013441192510.5802/crbiol.3610.5802/crbiol.36Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumoniaBastard, Paul0Zhang, Qian1Cobat, Aurélie2Jouanguy, Emmanuelle3Zhang, Shen-Ying4Abel, Laurent5Casanova, Jean-Laurent6Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; University of Paris, Imagine Institute, Paris, FranceSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USALaboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, FranceLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; University of Paris, Imagine Institute, Paris, FranceLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; University of Paris, Imagine Institute, Paris, FranceLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; University of Paris, Imagine Institute, Paris, FranceHoward Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Inserm U1163, Necker Hospital for Sick Children, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA; University of Paris, Imagine Institute, Paris, FranceWe established the COVID Human Genetic Effort (www.covidhge.com) to discover the human genetic and immunological bases of the vast interindividual clinical variability between humans infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We found that about 3% of patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia were ill because of inborn errors of genes controlling type I interferon (IFN)-dependent immunity (which controls influenza virus), and at least 10% of patients with life-threatening COVID-19 pneumonia had neutralizing auto-Abs against some of the 17 individual type I IFNs. These findings indicate that impaired type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 13% of patients. These discoveries pave the way for further research into unexplained severe cases, and provide a rationale for preventing and treating the disease in individuals at risk, with recombinant type I IFNs.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.36/Life-threatening COVID-19PneumoniaType I interferonsInborn errors of immunityAutoantibodies |
| spellingShingle | Bastard, Paul Zhang, Qian Cobat, Aurélie Jouanguy, Emmanuelle Zhang, Shen-Ying Abel, Laurent Casanova, Jean-Laurent Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia Comptes Rendus Biologies Life-threatening COVID-19 Pneumonia Type I interferons Inborn errors of immunity Autoantibodies |
| title | Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia |
| title_full | Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia |
| title_fullStr | Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia |
| title_full_unstemmed | Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia |
| title_short | Insufficient type I IFN immunity underlies life-threatening COVID-19 pneumonia |
| title_sort | insufficient type i ifn immunity underlies life threatening covid 19 pneumonia |
| topic | Life-threatening COVID-19 Pneumonia Type I interferons Inborn errors of immunity Autoantibodies |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.36/ |
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