Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal transition in regenerating pig hearts

Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal transition in regenerating pig hearts

Background: In our previous work, we demonstrated that when newborn pigs undergo apical resection (AR) on postnatal day 1 (P1), the animals’ hearts were completely recover from a myocardial infarction (MI) that occurs on postnatal day 28 (P28); single-nucleus RNA sequencing (snRNAseq) data suggested...

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Bibliographic Details
Main Authors: Thanh Minh Nguyen, Xiaoxiao Geng, Yuhua Wei, Lei Ye, Daniel J. Garry, Jianyi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
single-nucleus RNA-sequencing
heart
angiogenesis
endothelial cells
cell cycle
autoencoder
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1257669/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1257669/full

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