Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NE...

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Bibliographic Details
Main Authors: Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817310748

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http://www.sciencedirect.com/science/article/pii/S2212877817310748

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