Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways

Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways

Dysfunction of the cerebrovasculature plays an important role in vascular cognitive impairment (VCI). Lipotoxic injury of the systemic endothelium in response to hydrolyzed triglyceride-rich lipoproteins (TGRLs; TGRL lipolysis products) or a high-fat Western diet (WD) suggests similar mechanisms may...

Full description

Bibliographic Details
Main Authors: Hnin Hnin Aung, Robin Altman, Tun Nyunt, Jeffrey Kim, Saivageethi Nuthikattu, Madhu Budamagunta, John C. Voss, Dennis Wilson, John C. Rutledge, Amparo C. Villablanca
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Lipid Research
Subjects:
cell signaling
diet and dietary lipids
endothelial cells
gene expression
inflammation
lipolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351749

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520351749

Similar Items