TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway

Background: Cerebral ischemia-reperfusion injury (CIRI) inevitably occurs after vascular recanalization treatment for ischemic stroke. The accompanying inflammatory cascades have a major impact on outcome and regeneration after ischemic stroke. Evidences have demonstrated that TLR/MyD88/NF-κB signal...

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Bibliographic Details
Main Authors: Zeyang Li, Minghui Zhao, Xiaoqian Zhang, Yiran Lu, Yang Yang, Yalong Xie, Zhimiao Zou, Liang Zhou, Runshi Shang, Limin Zhang, Fengchao Jiang, Dunfeng Du, Ping Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
TJ-M2010-5
drug
cerebral ischemia-reperfusion injury
neuroinflammation
Myd88 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1080438/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1080438/full

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