TRAF3 negatively regulates platelet activation and thrombosis

TRAF3 negatively regulates platelet activation and thrombosis

Abstract CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation,...

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Bibliographic Details
Main Authors: Rui Zhang, Guoying Zhang, Binggang Xiang, Xiaofeng Chen, Lijang Tang, Shaojun Shi, Yani Liu, Xun Ai, Ping Xie, Zhenyu Li
Format: Article
Language:English
Published: Nature Portfolio 2017-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-17189-1

Internet

https://doi.org/10.1038/s41598-017-17189-1

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