ConDoR: tumor phylogeny inference with a copy-number constrained mutation loss model

ConDoR: tumor phylogeny inference with a copy-number constrained mutation loss model

Abstract A tumor contains a diverse collection of somatic mutations that reflect its past evolutionary history and that range in scale from single nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs). However, no current single-cell DNA sequencing (scDNA-seq) technology produces...

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Bibliographic Details
Main Authors: Palash Sashittal, Haochen Zhang, Christine A. Iacobuzio-Donahue, Benjamin J. Raphael
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Biology
Subjects:
Cancer
Intra-tumor heterogeneity
Tumor phylogeny
Single-cell DNA sequencing
Dollo model
Online Access:https://doi.org/10.1186/s13059-023-03106-5

Internet

https://doi.org/10.1186/s13059-023-03106-5

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