USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1

USP9X regulates the proliferation, survival, migration and invasion of gastric cancer cells by stabilizing MTH1

Abstract Background MutT homolog 1 (MTH1) sanitizes oxidized dNTP pools to promote the survival of cancer cells and its expression is frequently upregulated in cancers. Polyubiquitination stabilizes MTH1 to facilitate the proliferation of melanoma cells, suggesting the ubiquitin system controls the...

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Bibliographic Details
Main Authors: Wenji Xu, Yaping Zhang, Yingrui Su, Libin Li, Xinxia Yang, Lixing Wang, Hongzhi Gao
Format: Article
Language:English
Published: BMC 2024-07-01
Series:BMC Gastroenterology
Subjects:
MTH1
USP9X
Deubiquitination
Proliferation
Online Access:https://doi.org/10.1186/s12876-024-03321-9

Internet

https://doi.org/10.1186/s12876-024-03321-9

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