RARβ Expression in Keratinocytes from Potentially Malignant Oral Lesions: The Functional Consequences of Re-Expression by De-Methylating Agents

RARβ Expression in Keratinocytes from Potentially Malignant Oral Lesions: The Functional Consequences of Re-Expression by De-Methylating Agents

Loss of RARβ2 expression by promoter methylation is an early event in oral carcinogenesis. Understanding the mechanisms and consequences of RARβ loss may aid in understanding the disappointing results of retinoid chemoprevention trials. This study aimed to describe the effects of all-trans retinoic...

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Bibliographic Details
Main Authors: Raghu Radhakrishnan, Hannah L. Crane, Marc Daigneault, Kanaka Sai Ram Padam, Keith D. Hunter
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
RARβ
oral cancer
oral potentially malignant lesions
PMOL
retinoids
chemoprevention
Online Access:https://www.mdpi.com/2072-6694/13/16/4064

Internet

https://www.mdpi.com/2072-6694/13/16/4064

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