Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet
Clinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 % lard + 3 % corn oil) or HF + 5 % A...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646462400152X |
| _version_ | 1797235602083545088 |
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| author | Mario D'Ambrosio Elisabetta Bigagli Lorenzo Cinci Gianluca Cipriani Alberto Niccolai Natascia Biondi Liliana Rodolfi Francesca Zambelli Manuela Gencarelli Annunziatina Laurino Laura Raimondi Mario R. Tredici Cristina Luceri |
| author_facet | Mario D'Ambrosio Elisabetta Bigagli Lorenzo Cinci Gianluca Cipriani Alberto Niccolai Natascia Biondi Liliana Rodolfi Francesca Zambelli Manuela Gencarelli Annunziatina Laurino Laura Raimondi Mario R. Tredici Cristina Luceri |
| author_sort | Mario D'Ambrosio |
| collection | DOAJ |
| description | Clinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 % lard + 3 % corn oil) or HF + 5 % A. platensis F&M-C256 diet for 3 months. A. platensis F&M-C256 decreased blood triglycerides and total cholesterol, systolic and diastolic pressure and enhanced the expression of thermogenesis-related genes Prdm16, Dio2, PPARγ, Ucp1 and Lpl in visceral adipose tissue, compared to HF-diet. A. platensis reduced ANGPTL3 plasma levels and hepatic steatosis, prevented periaortic adipose tissue hypertrophy and increased aortic eNOS expression. These data provide some mechanistic evidence about the beneficial effects of A. platensis observed in human studies. Further controlled trials are needed to verify the clinical usefulness of A. platensis supplementation against metabolic disorders, to select the dosing regimens and the subgroup of patients with likelihood of benefit. |
| first_indexed | 2024-04-24T16:50:34Z |
| format | Article |
| id | doaj.art-5449590aeca943ca912cf5399626bce1 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-24T16:50:34Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-5449590aeca943ca912cf5399626bce12024-03-29T05:49:44ZengElsevierJournal of Functional Foods1756-46462024-05-01116106150Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat dietMario D'Ambrosio0Elisabetta Bigagli1Lorenzo Cinci2Gianluca Cipriani3Alberto Niccolai4Natascia Biondi5Liliana Rodolfi6Francesca Zambelli7Manuela Gencarelli8Annunziatina Laurino9Laura Raimondi10Mario R. Tredici11Cristina Luceri12Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy; Enteric Neuroscience Program, Department of Medicine, Section of Gastroenterology and Hepatology, Mayo Clinic, Rochester 55905, MN, United StatesDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy; Corresponding author.Department of Experimental and Clinical Biomedical Sciences, Radiodiagnostic Unit n. 2, Careggi University Hospital, Florence, ItalyEnteric Neuroscience Program, Department of Medicine, Section of Gastroenterology and Hepatology, Mayo Clinic, Rochester 55905, MN, United StatesDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, ItalyDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, ItalyDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy; Fotosintetica & Microbiologica S.r.l., Via di Santo Spirito 14, 50125 Florence, ItalyDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, ItalyDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, ItalyDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, ItalyDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, ItalyDepartment of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, ItalyDepartment of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, Florence 50139, ItalyClinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 % lard + 3 % corn oil) or HF + 5 % A. platensis F&M-C256 diet for 3 months. A. platensis F&M-C256 decreased blood triglycerides and total cholesterol, systolic and diastolic pressure and enhanced the expression of thermogenesis-related genes Prdm16, Dio2, PPARγ, Ucp1 and Lpl in visceral adipose tissue, compared to HF-diet. A. platensis reduced ANGPTL3 plasma levels and hepatic steatosis, prevented periaortic adipose tissue hypertrophy and increased aortic eNOS expression. These data provide some mechanistic evidence about the beneficial effects of A. platensis observed in human studies. Further controlled trials are needed to verify the clinical usefulness of A. platensis supplementation against metabolic disorders, to select the dosing regimens and the subgroup of patients with likelihood of benefit.http://www.sciencedirect.com/science/article/pii/S175646462400152XArthrospira platensisSpirulinaAdipose tissueLipid metabolismHigh-fat dietMetabolic syndrome |
| spellingShingle | Mario D'Ambrosio Elisabetta Bigagli Lorenzo Cinci Gianluca Cipriani Alberto Niccolai Natascia Biondi Liliana Rodolfi Francesca Zambelli Manuela Gencarelli Annunziatina Laurino Laura Raimondi Mario R. Tredici Cristina Luceri Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet Journal of Functional Foods Arthrospira platensis Spirulina Adipose tissue Lipid metabolism High-fat diet Metabolic syndrome |
| title | Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| title_full | Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| title_fullStr | Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| title_full_unstemmed | Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| title_short | Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| title_sort | arthrospira platensis f m c265 reduces cardiometabolic risk factors in rats fed a high fat diet |
| topic | Arthrospira platensis Spirulina Adipose tissue Lipid metabolism High-fat diet Metabolic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S175646462400152X |
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